Prof Elias Mossialos COW.4.08

Dr. Huseyin Naci

This course is compulsory on the MSc in Health Economics, Outcomes and Management in Cardiovascular Sciences. This course is not available as an outside option.

Against a backdrop of great technological advances and delivery system innovations, healthcare systems are facing daunting challenges. Over the past half- century, research on cardiovascular diseases has manifested remarkable advances in the prevention and treatment of cardiovascular diseases. Yet, great challenges remain, primarily due to a lack of strong research evidence about how best to provide care and organize ser vices to improve the quality, outcomes, and efficiency in health systems with a focus on cardiovascular diseases. Outcomes research aims to produce such evidence. In addition to briefly reviewing key epidemiological trends in cardiovascular diseases in Europe and globally, this course will introduce concepts about evidence-based medicine, quality of care, and outcomes-based accountability models. In particular, this module will focus on comparative effectiveness research as a framework for health care research and delivery. Comparative effectiveness research encompasses research efforts that aim to encourage healthcare decision-making to be increasingly based on comparative evidence on patient-centred outcomes at both the individual and population levels. In addition, this module teach the basics of study design in outcomes research and allow students to distinguish between strong and weak research design, and understand the methodological quality and risk of bias in different types of studies.

10 hours of lectures and 10 hours of seminars in the MT. 1 hour of help sessions in the ST.

5 brief response papers to each set of readings in preparation for each seminar.

Krumholz HM. Outcomes research: generating evidence for best practice and policies. Circulation 2008;118:309–18.

Ellwood PM. Shattuck lecture – outcomes management: a technology of patient experience. N Engl J Med 1988; 318: 1549–56.

Clancy CM et al. Outcomes research: measuring the end results of health care. Science 1998; 282: 245–46.

McGlynn EA. Six challenges in measuring the quality of health care. Health Affairs 1997;16.3:7–21.

Chalkidou et al. Comparative effectiveness research and evidence-based health policy: experience from four countries. Milbank Quarterly 2009:87.2: 339–67.

Cook TD. et al (1979). Quasi-experimentation: Design and Analysis Issues for Field settings. Boston, MA: Houghton Mifflin Company.

Concato J et al. Randomized, controlled trials, obser vational studies, and the hierarchy of research designs. N Engl J Med. 2000;342:1887–92.

Exam (75%, duration: 2 hours) in the main exam period.
Essay (25%, 3000 words) in the LT.